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Journal of the Korean Society of Pediatric Nephrology 2008;12(2): 227-232. doi: http://dx.doi.org/10.3339/jkspn.2008.12.2.227
학교 집단 요 검사 이상으로 추적검사 중 전신 홍반 루푸스로 진단된 1예
윤소진, 송지은, 신재일, 정일천, 이재승, 심효섭, 정현주
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
4연세대학교 의과대학 소아과학교실
5연세대학교 의과대학 소아과학교실
6연세대학교 의과대학 병리학교실
7연세대학교 의과대학 병리학교실
Diagnosis of Systemic Lupus Erythematosus During Medical Follow-up After Urinary Screening
So-Jin Yoon, Ji-Eun Song, Jae-Il Shin, Il-Cheon Jeong, Jae-Seung Lee, Hyo-Sup Shim, Hyeon-Joo Jeong
1The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Childrens Hospital
2The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Childrens Hospital
3The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Childrens Hospital
4The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Childrens Hospital
5The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Severance Childrens Hospital
6The Institute of Kidney Disease, Department of Pathology, Yonsei University College of Medicine, Severance Childrens Hospital
7The Institute of Kidney Disease, Department of Pathology, Yonsei University College of Medicine, Severance Childrens Hospital
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ABSTRACT
A 16-year-old girl presented with proteinuria and microscopic hematuria detected through mass urinary screening and was diagnosed as having suspected postinfectious glomerulonephritis by renal biopsy. However, heavy proteinuria did not respond to angiotensin converting enzyme inhibitor therapy. After 6 months, cervical lymphadenitis developed and a neck node biopsy showed subacute necrotizing lymphadenitis. After an additional 2 months, she developed facial erythema and thrombocytopenia. A repeat renal biopsy demonstrated lupus nephritis class IV. She was treated with pulse methylprednisolone(500 mg/day intravenously for 3 consecutive days) followed by oral deflazacort and monthly intravenous cyclophosphamide pulse(1 g/$m^2$) for 6 months. We report a case diagnosed as systemic lupus erythematosus(SLE) during medical follow-up after urinary screening.
Key words: Systemic lupus erythematosus(SLE) | Lupus nephritis(LN)
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