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Journal of the Korean Society of Pediatric Nephrology 2009;13(1): 75-83. doi: https://doi.org/10.3339/jkspn.2009.13.1.75
체질량 지수 25 이상의 과체중군에서 신장질환과 관련된 인자들에 대한 연구
최아름, 박성신, 김성도, 조병수
1경희대학교 의과대학 소아과학교실
2경희대학교 의과대학 소아과학교실
3경희대학교 의과대학 소아과학교실
4경희대학교 의과대학 소아과학교실
Research Related to Chronic Kidney Disease in BMI >25 Overweight Children
Ah-Reum Choi, Sung-Sin Park, Sung-Do Kim, Byoung-Soo Cho
1Department of Pediatrics, College of Medicine, Kyunghee University
2Department of Pediatrics, College of Medicine, Kyunghee University
3Department of Pediatrics, College of Medicine, Kyunghee University
4Department of Pediatrics, College of Medicine, Kyunghee University
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Purpose : Chronic kidney disease (CKD) and obesity are the worldwide public health problem. Obesity is an already well-established risk factor for CKD. The objective of this study is to evaluate the relationship between high BMI and increased risk for nephropathy by clinical data.
Methods : Study group were 26 patients who had $BMI{geq}25;kg/m^2$ and control group were 49 patients with BMI<$25;kg/m^2$. Both groups received renal biopsy in Kyung Hee Medical Center between 2003. Jan.-2007. Dec. BMI was calculated from measured weight and height when they were admitted to the hospital. We collected laboratory data such as CBC and blood chemistry.
Results : Our hypothesis was that overweight and obesity are associated with incidence and progression of CKD. From kidney biopsy, we found IgAN 17, MesPGN 5, HSPN 2, Intestitial nephritis 1, IgMN 1 (total 26) in the study group whereas IgAN 22, MesPGN 17, HSPN 3, MGN 3, benign hematuria 2, MPGN 1, Intestitial nephritis 1, (total 49) were found in the control group. There was no significant difference between the two groups. Overweight patients demonstrated significantly higher platelet, TG, ALT, and uric acid level compared to control group.
Conclusion : We identified a significant relationship between overweight and development of CKD. These results suggest that overweight children have an increased risk for CKD than those who are not obese. So, we should pay attention to children with overweight who have CKD and earlier weight management is crucial to prevent aggravation of CKD.
Key words: BMI | Chronic kidney disease (CKD) | Laboratory data | Result of kidney biopsy
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Slowing the Progression of Chronic Kidney Disease in Children and Adolescents  2010 April;14(1)
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