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Journal of the Korean Society of Pediatric Nephrology 1999;3(2): 145-152.
대전지역 소아 신증후군의 임상병리학적 및 역학적 연구
임삼화, 윤계남, 차상원, 이동준, 한지환, 황경태, 이경일
1가톨릭대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 소아과학교실
3가톨릭대학교 의과대학 소아과학교실
4가톨릭대학교 의과대학 소아과학교실
5가톨릭대학교 의과대학 소아과학교실
6가톨릭대학교 의과대학 소아과학교실
7가톨릭대학교 의과대학 소아과학교실
Clinicopathologic and Epidemiologic Study of Childhood Nephrotic Syndrome in Taejon, Korea
Sam-Hwa Yim, Kye-Nam Yoon, Sang-Won Cha, Dong-Joon Lee, Ji-Whan Han, Kyung-Tae Whang, Kyung-Yil Lee
1Department of Pediatrics, The Catholic University of Korea, College of Medicine
2Department of Pediatrics, The Catholic University of Korea, College of Medicine
3Department of Pediatrics, The Catholic University of Korea, College of Medicine
4Department of Pediatrics, The Catholic University of Korea, College of Medicine
5Department of Pediatrics, The Catholic University of Korea, College of Medicine
6Department of Pediatrics, The Catholic University of Korea, College of Medicine
7Department of Pediatrics, The Catholic University of Korea, College of Medicine
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ABSTRACT
Purpose: The prevalence of childhood renal diseases including the nephrotic syndrome in Korea has not been well established. In priority to this point, we analyzed ninety-six nephrotic children of the annual incidence, the ratio of them to all inpatients and estimated incidence of childhood nephrotic syndrome under 15 years of age in Taejon, Korea. Also we classified them by clinical and histopathological findings.
Methods: we analyzed the admission and outpatient records retrospectively between June 1986 and December 1998. For the estimation of incidence, we were assisted with three other general hospitals in Taejon
Results : The mean annual number and the ratio to inpatients were $7.4{pm}2.1,;0.3{pm}0.11%$ respectively. The latter showed a tendency to decrease during the recent three years. The estimated annual incidences of childhood nephrotic syndrome in Taejon were 5.6 in 1988, 5.5 in 1993 and 4.8 in 1998 per 100,000 for children aged up to 15 years. The mean age of our patients was $6.8{pm}3.5$ tears, 1-7 years of age was 55 cases(57.3%), and male to female ratio was 3.6:1. By the clinicopathologic classification, 89 cases(92.7%) were classified as primary nephrotic syndrome, and 7 cases(7.3%) as secondary nephrotic syndrome. Among the primary nephrotic syndrome, there was 79.8% of minimal change nephrotic syndrome, focal segmental glomerulosclerosis 11.2%, mesangial proliferation 4.5%, membranoproliferative glomerulonephritis 3.4%, and membranous nephropathy 1.1%. $Henoch-Sch""{o}nlein$ nephritis was the most frequent of 3 cases in the secondary nephrotic syndrome. Respones to steroid therapy of 71 cases minimal change were classified as non-relapse 22.5%, non-frequent relapse 49.3%, frequent relapse 18.3% and steroid-dependence 9.9%.
Conclusion : The estimated incidence of childhood nephrotic syndrome was about 5 per 100,000 for children aged up to 15 years and it showed little changes during 10 years in Taejon, Korea. Our results of clinicopathologic study was little difference from the results reported in other literatures.
Key words: Nephrotic syndrome | Children | Clinicopathology | Epidemiology
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