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Journal of the Korean Society of Pediatric Nephrology 2000;4(1): 84-91.
소아 신이식 후의 키 성장에 영향을 미치는 인자들에 대한 연구
이주훈, 이병섭, 강희경, 한혜원, 이준호, 하일수, 정해일, 최용, 김상준
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5서울대학교 의과대학 소아과학교실
6서울대학교 의과대학 소아과학교실
7서울대학교 의과대학 소아과학교실
8서울대학교 의과대학 소아과학교실
9서울대학교 의과대학 외과학교실
Analysis of Factors Affecting Height Growth After Renal Transplantation in Children
Joo Hoon Lee, Byong Sop Lee, Hee-Gyung Kang, Hyewon Hahn, Jun Ho Lee, Il Soo Ha, Hae Il Cheong, Yong Choi, Sang Joon Kim
1Department of Pediatrics, Seoul National University, College of Medicine
2Department of Pediatrics, Seoul National University, College of Medicine
3Department of Pediatrics, Seoul National University, College of Medicine
4Department of Pediatrics, Seoul National University, College of Medicine
5Department of Pediatrics, Seoul National University, College of Medicine
6Department of Pediatrics, Seoul National University, College of Medicine
7Department of Pediatrics, Seoul National University, College of Medicine
8Department of Pediatrics, Seoul National University, College of Medicine
9Department of Surgery, Seoul University, College of Medicine
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ABSTRACT
Purpose: To improve the recovery of growth deficit after renal transplantation in children, we analysed the factors affecting height growth after renal transplantation.
Methods: We reviewed medical records of fifty-six children in whom height data were available for three years after transplantation. All height data were converted into Z-scores. We analyzed the effects of sex, age at transplantation, cumulative mean steroid dose for 3 years, serum creatinine levels, height at transplantation, donor source and history of prior dialysis on patients' z-scores and delta Zs.
Results : The Z-scores at transplantation were lower in patients of younger age (P=0.007). When baseline Z-scores were lower, the delta Zs were higher (P<0.01), but the Z-scores after transplantation were still lower (P<0.001). According to the analysis of the partial correlation coefficients, Z-scores and delta Zs at 1 year after transplantation were higher in groups of younger age and of lower steroid dosages (P<0.05). The delta Zs at 6 month and 1 year after transplantation were lower in the group with abnormally higher serum creatinine (P<0.05). There was no difference in Z-scores between groups of different genders, donor sources, and histories of previous dialysis.
Conclusion : The children of younger age, on lower steroid dosage, with less growth retardation at transplantation, and with normal graft function had better height growth recoveries after renal transplantation.
Key words: Height growth | Renal transplantation | Children | Age | Steroid dosage | Serum creatinine
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