Two cases of Hemolytic Uremic Syndrome Associated with Esecherichia coli O114

Ryu, Su-Jeung; Hahn, Hyewon; Yoo, Soo Jin; Lee, Byung-Sun; Lee, Jae Kyoo; Kim, Mi-Na; Kim, Eui Chong; Park, Young Seo

J Korean Soc Pediatr Nephrol > Volume 6(1); 2002 > Article

J Korean Soc Pediatr Nephrol 2002;6(1): 102-108.

Escherichia coli O114에 의한 용혈성 요독 증후군 2례

류수정, 한혜원, 유수진, 이병선, 이재규, 김미나, 김의종, 박영서

¹울산대학교 의과대학 서울아산병원 소아과
²울산대학교 의과대학 서울아산병원 소아과
³울산대학교 의과대학 서울아산병원 임상병리학과
⁴울산대학교 의과대학 서울아산병원 소아과
⁵서울대학교 의과대학 임상병리학과
⁶울산대학교 의과대학 서울아산병원 임상병리학과
⁷서울대학교 의과대학 임상병리학과
⁸울산대학교 의과대학 서울아산병원 소아과

Two cases of Hemolytic Uremic Syndrome Associated with Esecherichia coli O114

Su-Jeung Ryu, Hyewon Hahn, Soo Jin Yoo, Byung-Sun Lee, Jae Kyoo Lee, Mi-Na Kim, Eui Chong Kim, Young Seo Park

¹Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine
²Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine
³Department of Clinical Pathology, Asan Medical Center, University of Ulsan, College of Medicine
⁴Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine
⁵Seoul National University College of Medicine, Department of Clinical Pathology
⁶Department of Clinical Pathology, Asan Medical Center, University of Ulsan, College of Medicine
⁷Seoul National University College of Medicine, Department of Clinical Pathology
⁸Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine

ABSTRACT

We report two cases of hemolytic uremic syndrome (HUS) associated with Escherichia coli O114. Two cases were similar and showed the same clinical courses. After prodrome of diarrhea and vomiting lasting 1-2 days, azotemia persisted for about 10 days, and during that period, the patients were on peritoneal dialysis. They recovered without any sequelae after about 15 days. Direct multiplex PCR of stool culture revealed eae and stx2 gene and the result of ELISA done on the colony positive of one gene confirmed Escherichia coli O114. This is the first report of HUS associated with Escherichia coli O114. We recommend, Shiga toxin producing bacterial Infection must be considered and efforts should be made to scrutinize the organism in all diarrhea-prodrome HUS patients.(J Korean Soc Pediatr Nephrol 2002 ;6 : 102-8)

Key words: Hemolytic Uremic Syndrome | Shiga toxin | Escherichia coli O114