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Journal of the Korean Society of Pediatric Nephrology 2003;7(2): 229-233.
소아 악성 고열증과 동반되어 발생한 횡문근융해증 1례
이범희, 이진숙, 조희연, 강주형, 강희경, 정해일, 최용, 하일수
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5서울대학교 의과대학 소아과학교실
6서울대학교 의과대학 소아과학교실
7서울대학교 의과대학 소아과학교실
8서울대학교 의과대학 소아과학교실
A Case of Childhood Malignant Hyperthermia Complicated by Rhabdomyolysis
Bum-Hee Lee, Jin-Sook Lee, Hee-Yeon Cho, Ju-Hyung Kang, Hee-Gyung Kang, Hae-Il Cheong, Yong Choi, Il-Soo Ha
1Department of Pediatrics, Seoul National University College of Medicine
2Department of Pediatrics, Seoul National University College of Medicine
3Department of Pediatrics, Seoul National University College of Medicine
4Department of Pediatrics, Seoul National University College of Medicine
5Department of Pediatrics, Seoul National University College of Medicine
6Department of Pediatrics, Seoul National University College of Medicine
7Department of Pediatrics, Seoul National University College of Medicine
8Department of Pediatrics, Seoul National University College of Medicine
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ABSTRACT
Mortality and morbidity of malignant hyperthermia has decreased markedly by the avoidance of succinylcholine, and the earlier detection and introduction of dantrolene. We report a fourteen-year-old boy who developed malignant hyperthermia during general anesthesia. He showed the earlier clinical signs, such as elevation of end-tidal $CO_2$, tachycardia, and hypertension. After prompt administration of dantrolene, operation was continued with profopol and midazolam. Rhabdomyolysis and myoglobinuria followed, and were managed by hydration and alkalinization of urine. Azotemia did not occur, and he was discharged without any sequelae on the $10^{th}$ postoperative day.
Key words: Dantrolene | General anaesthesia | Rhabdomyolysis | Malignant hyperthermia
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