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Journal of the Korean Society of Pediatric Nephrology 2005;9(1): 21-30.
신질환 환아에서 초음파 골량측정법을 이용한 골상태 평가
강주형, 신윤혜, 조남한, 배기수
1을지대학교 의과대학 소아과학교실
2아주대학교 의과대학 소아과학교실
3아주대학교 의과대학 예방의학교실
4아주대학교 의과대학 소아과학교실
Assesment of Bone Strength Using a New Quantitative Ultrasound Device in Children with Renal Diseases
Ju-Hyung Kang, Yun-Hye Shin, Nam-Han Cho, Ki-Soo Pai
1Departments of Pediatrics, College of Medicine, Eulji University
2Departments of Pediatrics, College of Medicine, Ajou University
3Departments of Preventive, College of Medicine, Ajou University
4Departments of Pediatrics, College of Medicine, Ajou University
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ABSTRACT
Purpose : Metabolic bone diseases have been mai or problems in children with renal diseases and steroid treatment is the main precipitating factor reducing bone mineral density(BMD). This study was performed to assess the prevalence of osteoporosis and to evaluate the clinical factors associated with decreased BMD in children with renal diseases.
Methods : Forty-four children with renal diseases who were diagnosed at the Pediatric no phrology division of Ajou University hospital since Oct. 1994 were included. Using a new quantitative ultrasound device, BMD and the prevalence of osteoporosis were evaluated. The clinical and serological data were analyzed in association with decreased BMD.
Results : A total of 44 patients were evaluated. The age at initial diagnosis was 6.7$pm$4.2 years. At the time of evaluation, the chronological and bone age was 9.3$pm$4.2 years and 8.2 $pm$ 4.6 years, respectively. The renal diseases included nephrotic syndrome 24(54.5%), Henoch Schonlein purpura nephritis 7(15.9%), IgA nephropathy 6(13.9%), reflux nephropathy(RN) 2 (4.5%), and other renal disease 5(%). The prevalence of osteoporosis was 11%. There was no difference in the clinical factors between the long-term and the short-term treated steroid groups.
Conclusion : The prevalence of osteoporosis was 12% in 44 children with renal diseases No significant factor was found in association with decreased BMD and there was no relationship between osteoporosis and steroid usage duration or cumulative dose. A new quantitative ultrasound, which is relatively easy to perform, especially in children, is expected to be in common use and will enable clinicians to evaluate metabolic bone disorders with ease.
Key words: Nephrotic syndrome | Osteoporosis | Bone mineral density | Quantitative ultrasound device
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