| Home | E-Submission | Sitemap | Contact Us |  
Journal of the Korean Society of Pediatric Nephrology 2005;9(2): 143-148.
소아 신증후군에서 IgG 아군 및 바이러스 항체 값
송용훈, 이경일, 김동언, 고대균, 이병철
1가톨릭대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 소아과학교실
3가톨릭대학교 의과대학 소아과학교실
4가톨릭대학교 의과대학 소아과학교실
5가톨릭대학교 의과대학 소아과학교실
The Levels of IgG Subclasses and Vaccine-induced Viral Antibodies in Childhood Minimal Change Nephrotic Syndrome
Yong-Hoon Song, Kyung-Yil Lee, Dong-Un Kim, Dae-Kyun Koh, Byung-Churl Lee
1Department of Pediatrics, College of Medicine, The Catholic University of Korea
2Department of Pediatrics, College of Medicine, The Catholic University of Korea
3Department of Pediatrics, College of Medicine, The Catholic University of Korea
4Department of Pediatrics, College of Medicine, The Catholic University of Korea
5Department of Pediatrics, College of Medicine, The Catholic University of Korea
Share :  
ABSTRACT
Purpose : Hypogammaglobulinemia has been observed in nephrotic syndrome, but its pathophysiology remains unknown. We evaluated serum immunoglobulins, IgG subclasses, and vaccine-induced viral antibodies(anti-hepatitis B surface IgG and anti-measles IgG) in children with minimal change nephrotic syndrome(MCNS).
Methods : Using the stored sera, the levels of immunoglobulin(IgC, IgM, IgA, and IgC) and IgG subclasses(IgG 1, 2, ,3, and 4), anti-HBs Ab and anti-measles IgG of 21 children with MCNS were analyzed and compared to those of 25 age-matched healthy children.
Results : The mean values of IgG and IgG1 were $390{pm}187;mg/dL$ and $287{pm}120;mg/dL$ in nephrotic children, and $1,025{pm}284;mg/dL$ and $785{pm}19;mg/dL$ in control children, respectively. The values of the total IgG and the 4 IgG subclasses in nephrotic children were all significantly depressed(P<0.001), but the IgM($251{pm}183;mg/dL;vs. 153{pm}55;mg/dL$, P=0.02) and IgE values(P=0.01) were elevated, and the IgA values were not changed. The seropositivity of anti-HBs IgG was 42.9$%$(9 of 21 cases) in the MCNS group and 52$%$(13/25) in the control group, and that of anti-measles IgG was 75$%$(16/21) and 92$%$(23/25), respectively, but there was no statistical difference between the two groups.
Conclusion : IgG and IgG subclass levels in MCNS children are all depressed without significant seronegativity of the vaccine-induced viral antibodies. Further studies are needed to resolve the cause of hypogammaglobulinemia in MCNS. (J Korean Soc Pediatr Nephrol 2005;9:143-148)
Key words: Minimal change nephrotic syndrome | Children | Immunoglobulins | IgG subclasses | Anti-hepatitis B suface antibody | Anti-measles IgG
Editorial Office
124 Bukbyunjeung-ro, Kimpo, Jesewoong 2-103, Gyeonggi-do 10098, Republic of Korea
TEL : +82-31-987-5963   FAX : +82-31-987-5967   E-mail : chikd.editor@gmail.com or ckdeditor@kspn.org

Copyright© Korean Society of Pediatric Nephrology. All rights reserved.                powerd by m2community
About |  Browse Articles |  Current Issue |  For Authors and Reviewers