The Relationship Between Interleukin 1β Gene Polymorphism and Renal Involvement in Henoch-Schönlein Purpura

Na, Hyoung-Joon; Go, Il-Yong; Yoon, Joon-Ho; Yeh, Byung-Il; Kim, Hwang-Min

J Korean Soc Pediatr Nephrol > Volume 10(2); 2006 > Article

J Korean Soc Pediatr Nephrol 2006;10(2): 125-131.

Henoch-Schönlein Purpura에서 Interleukin 1β 유전자 다형성과 신장 침범과의 연관성

나형준, 고일용, 윤준호, 예병일, 김황민

¹연세대학교 원주의과대학 소아과학교실, 생화학교실
²연세대학교 원주의과대학 소아과학교실, 생화학교실
³연세대학교 원주의과대학 소아과학교실, 생화학교실
⁴연세대학교 원주의과대학 소아과학교실, 생화학교실
⁵연세대학교 원주의과대학 소아과학교실, 생화학교실

The Relationship Between Interleukin 1β Gene Polymorphism and Renal Involvement in Henoch-Schönlein Purpura

Hyoung-Joon Na, Il-Yong Go, Joon-Ho Yoon, Byung-Il Yeh, Hwang-Min Kim

¹Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine
²Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine
³Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine
⁴Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine
⁵Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine

ABSTRACT

Purpose : High interleukin-1 beta(IL-1β) expression in the skin biopsy specimens of patients with Henoch-Schönlein Purpura(HSP) has been observed. We examined IL-1β gene polymorphism in patients with HSP. The purpose of this study is to examine the relationship between IL-1β gene polymorphism and renal involvement in HSP.
Methods : Patients from mideast Korea with HSP were studied. All patients had at least 6 months of follow up. Patients and ethnically matched controls were genotyped for IL-1βgene polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).
Results : Thirty-four patients(all younger than 15 years old) who had been diagnosed with HSP and 27 controls were examined. No allele or genotype differences between the HSP and control groups were observed. No significant association between the carriage of IL-1β(-511) T allele and renal involvement(P=0.525, OR:1.417, CI:0.545-3.686) was found.
Conclusion : In unselected patients with HSP, carriage of IL-1β(-511) T allele does not appear to influence renal involvement.

Key words: Henoch-Schönlein purpura | IL-1β polymorphism | Renal involvement