The Clinical Significance of Antiphospholipid Antibodies in Korean Children with Henoch-Schönlein Purpura

Park, Eun-Jung; Baek, Ji-Young; Shin, Jae-Il; Lee, Jae-Seung; Kim, Hyon-Suk

doi:2009.13.2.146

J Korean Soc Pediatr Nephrol > Volume 13(2); 2009 > Article

J Korean Soc Pediatr Nephrol 2009;13(2): 146-152. doi: https://doi.org/10.3339/jkspn.2009.13.2.146

Henoch-Schönlein 자반증에서 항인지질 항체의 임상적 의의

박은정, 백지영, 신재일, 이재승, 김현숙

¹연세대학교 의과대학 소아과학교실
²연세대학교 의과대학 소아과학교실
³연세대학교 의과대학 소아과학교실
⁴연세대학교 의과대학 소아과학교실
⁵연세대학교 의과대학 진단검사의학교실

The Clinical Significance of Antiphospholipid Antibodies in Korean Children with Henoch-Schönlein Purpura

Eun-Jung Park, Ji-Young Baek, Jae-Il Shin, Jae-Seung Lee, Hyon-Suk Kim

¹Department of Pediatrics, Yonsei University college of Medicine
²Department of Pediatrics, Yonsei University college of Medicine
³Department of Pediatrics, Yonsei University college of Medicine
⁴Department of Pediatrics, Yonsei University college of Medicine
⁵Department of Laboratory Medicine, Yonsei University college of Medicine

ABSTRACT

Purpose : We performed this study to evaluate the incidence and clinical significance of antiphospholipid antibodies (aPL Ab) in Korean children with Henoch-$Sch{ddot{o}}nlein$ purpura (HSP).
Methods : The medical records of 62 patients (31 boys and 31 girls) aged $46.0{pm}3.1$ (1-16) years with a clinical diagnosis of HSP based on the EULAR/PReS criteria were reviewed retrospectively. From the years 2007 to 2009, the sera from children with acute HSP were tested for aPL Ab such as LA, anti-cardiolipin antibody and anti-${beta}_2$ glycoprotein I antibody.
Results : LA was positive in 18 (29%) of the 62 patients with HSP and We divided the patients into the two groups LA positive group (N=18) and LA negative group (N=44). There were no significant differences between the two groups with regard to abdominal pain, arthralgia and renal involvement, but LA positive group had significantly higher C-reactive protein ($4.3{pm}7.2$ mg/dL vs. $1.3{pm}1.8$ mg/dL, P=0.035), erythrocyte sedimentation rate ($37.5{pm}26.2$ mm/hr vs. $25.1{pm}22.6$ mm/hr, P= 0.039), IgM ($148.1{pm}48.4$ mg/dL vs. $114.9{pm}41.5$ mg/dL, P=0.024), C3 ($143.1{pm}21.9$ mg/dL vs. $129.7{pm}24.5$ mg/dL, P=0.048) and C4 levels ($30.9{pm}6.3$ mg/dL vs. $24.9{pm}7.8$ mg/dL, P=0.002) compared with LA negative group.
Conclusion : We found that the incidence of positive aPL Ab tests was relatively higher in Korean children with HSP and the presence of aPL Ab was associated with acute inflammatory process of HSP. These results suggest that the aPL Ab are involved in the pathogenesis of HSP in children.

Key words: Henoch-$Sch{\ddot{o}}nlein$ purpura | Antiphospholipid antibodies | Lupus anticoagulant