Cardiovascular Disease in Pediatric Chronic Kidney Disease.

, Cho, Min Hyun

doi:2014.18.1.7

Child Kidney Dis > Volume 18(1); 2014 > Article

Review Article

J Korean Soc Pediatr Nephrol 2014;18(1): 7-12. doi: https://doi.org/10.3339/jkspn.2014.18.1.7

Cardiovascular Disease in Pediatric Chronic Kidney Disease.

Cho, Min Hyun

Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. chomh@knu.ac.kr

ABSTRACT

Cardiovascular disease (CVD) has been identified as one of the most important factors influencing the long-term prognosis of patients with chronic kidney disease (CKD). However, in pediatric CKD, the clinical importance of CVD tends to be overlooked due to the lack of typical manifestations of CVD in this population. The literature has identified several traditional risk factors of CVD that originate from CKD, including hypertension, diabetes mellitus, dyslipidemia and obesity, in addition to new and non-traditional risk factors including anemia, secondary hyperparathyroidism, oxidative stress and inflammation. In cases of pediatric CKD, cardiovascular disease is usually restricted to subclinical manifestations such as left ventricular hypertrophy, thickening of intimal media on the carotid artery and calcification of the coronary artery. Therefore, risk factors of CVD in pediatric CKD patients should be closely monitored.

Key words: Cardiovascular disease | Children | Chronic kidney disease