Prognostic Factors in Childhood IgA Nephropathy

Park, Jae-Hyun; Kim, Pyung-Kil; Jeong, Hyeon-Joo; Choi, In-Joon

J Korean Soc Pediatr Nephrol > Volume 1(1); 1997 > Article

J Korean Soc Pediatr Nephrol 1997;1(1): 17-23.

소아 IgA 신병증의 예후에 관한 고찰

박재현, 김병길, 정현주, 최인준

¹연세대학교 의과대학 소아과학교실
²연세대학교 의과대학 소아과학교실
³연세대학교 의과대학 병리학교실
⁴연세대학교 의과대학 병리학교실

Prognostic Factors in Childhood IgA Nephropathy

Jae-Hyun Park, Pyung-Kil Kim, Hyeon-Joo Jeong, In-Joon Choi

¹Departments of Pediatrics, Yonsei University, College of Medicine
²Departments of Pediatrics, Yonsei University, College of Medicine
³Departments of Pathology, Yonsei University, College of Medicine
⁴Departments of Pathology, Yonsei University, College of Medicine

ABSTRACT

After the first description of IgA nephropathy by Berger in 1968, the prognosis of this disease was considered favourable. However recent studies have revealed that IgA nephropathy result in end stage renal desease in 25-30% by 20 years. Heavy proteinuria, hypertension, histological high class are regarded as poor prognostic factors. In 1996, Yagame et al reported the new histopathologic grading with a strong correlation between the grading, heavy proteinuria, high s-Cr level and renal survival. The aims of this study are to determine whether the pathological grading and other clinical parameters could contribute to predicting the outcome of this disease eventhough pediatric patients. Seventy nine patients (59 males, 20 females) with IgA nephropathy were examined. Patients were 2.08-15.17 years of age ($9.85{pm}2.83$). The mean follow-up duration were $27{pm}28$ months. Six of seventy nine patients progressed to chronic renal failure during the follow-up periods. High 24h urinary protein excretion at diagnosis were significantly higher in chronic renal failure patients (p<0.05). Hypertension at diagnosis were the significant associated factors in progression of chronic renal failure (p<0.05). Histological changes of IgA nephropathy in light microscopy were classified into five classes by WHO classification, four grades in Yagame's gradings. Among the seventy nine patients, 24 were as class 1, 30 as class 2, 23 as class 3; 4 as class 4, 0 as class 5 by WHO classification. 23 were classified grade 1, 31 as grade 2, 24 as grade 3, 1 as grade 4 by Yagame's grading. Among six patients who progressed to chronic renal failure, 1 clssified as class 1, 1 as class 2, 3 as class 3, 1 as class 4, 0 as class 5 by WHO Classification. 1 patients were classified as grade 1, 1 as grade 2, 3 as grade 3, 1 as grade 4 by Yagame's grading. (p>0.05) In conclusion, hypertension and heavy proteinuria at initial presentation were significantly associated with progression of chronic renal failure. The classification of WHO & Yagame's grading has no significant association with the progression of chronic renal failure in pediatric patients.

Key words: IgA nephropathy | Classification | Hypertension | Proteinuria