A Case of Posterior Reversible Encephalopathy Syndrome during Cyclosporine Therapy in a Child with Steroid Resistant Nephrotic Syndrome

Jeong, Min-Hee; Lee, Joo-Hoon; Yum, Mi-Sun; Ko, Tae-Sung; Park, Young-Seo

doi:2007.11.1.92

J Korean Soc Pediatr Nephrol > Volume 11(1); 2007 > Article

J Korean Soc Pediatr Nephrol 2007;11(1): 92-99. doi: https://doi.org/10.3339/jkspn.2007.11.1.92

스테로이드 저항성 신증후군 환아에서 사이클로스포린 투여 중 발생한 후두엽 가역성 뇌병증 증후군 1례

정민희, 이주훈, 염미선, 고태성, 박영서

¹울산대학교 의과대학 아산병원 소아과
²울산대학교 의과대학 아산병원 소아과
³울산대학교 의과대학 아산병원 소아과
⁴울산대학교 의과대학 아산병원 소아과
⁵울산대학교 의과대학 아산병원 소아과

A Case of Posterior Reversible Encephalopathy Syndrome during Cyclosporine Therapy in a Child with Steroid Resistant Nephrotic Syndrome

Min-Hee Jeong, Joo-Hoon Lee, Mi-Sun Yum, Tae-Sung Ko, Young-Seo Park

¹Department of pediatrics, Asan Medical Center, College of Medicine University of Ulsan
²Department of pediatrics, Asan Medical Center, College of Medicine University of Ulsan
³Department of pediatrics, Asan Medical Center, College of Medicine University of Ulsan
⁴Department of pediatrics, Asan Medical Center, College of Medicine University of Ulsan
⁵Department of pediatrics, Asan Medical Center, College of Medicine University of Ulsan

ABSTRACT

The posterior reversible encephalopathy syndrome(PRES) is characterized clinically by a combination of acute or subacute confusion, lethargy, visual disturbance, and seizures. PRES has been described in various clinical settings, including severe hypertension, chemotherapy, eclampsia, and seizure. We report a case of a 7-year-old girl who had taken cyclosporine for steroid resistant nephrotic syndrome. Twenty one days after the cyclosporine therapy, she was admitted due to generalized tonic clonic seizure and headache. Her blood pressure was 170/90 mmHg. Magnetic resonance(MR) imaging showed necrotic/cystic lesions involving the bilateral parieto-occipital region. After discontinuation of cyclosporine, and control of blood pressure, she had no more seizure and headache. The follow-up MR examination which was performed 6 months later showed the decreased extent of the lesion.

Key words: Steroid resistant nephrotic syndrome | Posterior reversible encephalopathy syndrome | Cyclosporine