Renal Toxicity of High-dose Intravenous Immunoglobulin in Children with Kawasaki Disease and Idiopathic Thrombocytopenic Purpura

Jung, Ji Ah; Kim, Hye Soon; Seo, Jeong Wan; Lee, Seung Joo

J Korean Soc Pediatr Nephrol > Volume 2(2); 1998 > Article

J Korean Soc Pediatr Nephrol 1998;2(2): 133-137.

가와사끼병과 특발성 혈소판 감소성 자반증 환아에서 고용량 정주용 면역글로불린의 신독성 유무

정지아, 김혜순, 서정완, 이승주

¹이화여자대학교 의과대학 소아과학교실
²이화여자대학교 의과대학 소아과학교실
³이화여자대학교 의과대학 소아과학교실
⁴이화여자대학교 의과대학 소아과학교실

Renal Toxicity of High-dose Intravenous Immunoglobulin in Children with Kawasaki Disease and Idiopathic Thrombocytopenic Purpura

Ji Ah Jung, Hye Soon Kim, Jeong Wan Seo, Seung Joo Lee

¹Department of Pediatrics, Ewha Woman University, College of Medicine
²Department of Pediatrics, Ewha Woman University, College of Medicine
³Department of Pediatrics, Ewha Woman University, College of Medicine
⁴Department of Pediatrics, Ewha Woman University, College of Medicine

ABSTRACT

Purpose : To investigate renal toxicity of high-dose intravenous immunoglobulin(IVIG) in children with Kawasaki disease and idiopathic thrombocytopenic purpura.
Methods : 23 children with Kawasaki disease and 7 children with idiopathic thrombocytopenic purpura who were treated with high-dose IVIG(2 g/kg) were evaluated for the change of urine output, blood urea nitrogen(BUN), serum creatinine(Scr), creatinine clearance(Ccr), tubular reabsorption of phosphorus(TRP), fractional excretion of sodium(FENa), 24hour urine ${beta}_2$-microglobulin/creatinine(${beta}_{2}MG/cr$) ratio and urine microalbumin/creatinine(MA/cr) ratio at post-IVIG 1 and 3 day.
Results : There was no significant change of urine output, BUN, Scr, Ccr, TRP, 24hour urine ${beta}_{2}MG/cr$ and MA/cr ratio after high-dose IVIG treatment. Transient increase of FENa at post-IVIG 1 day was the only significant change.
Conclusion : There was no significant renal toxicity of high-dose IVIG in children with Kawasaki disease and idiopathic thrombocytopenic purpura who had normal renal function.

Key words: IVIG | Renal Toxicity