J Korean Soc Pediatr Nephrol > Volume 3(1); 1999 > Article
J Korean Soc Pediatr Nephrol 1999;3(1): 42-47.
ACE inhibitor가 소아 신증후군에서 단백뇨 소실에 미치는 영향
박은혜, 김지홍, 김병길
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
Effect of ACE Inhibitor on Nephrotic Proteinuria in the Children
Eun-Hye Park, Ji-Hong Kim, Pyung-Kil Kim
1Department of Pediatrics, Yonsei University, College of Medicine
2Department of Pediatrics, Yonsei University, College of Medicine
3Department of Pediatrics, Yonsei University, College of Medicine
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Angiotensin-converting enzyme inhibitors lower urinary protein excretion in hypertensive and normotensive patients with renal disease. Most children with nephrotic syndrome have minimal change histology and the great majority of these patients respond to the treatment with oral prednisone. Here we have studied the effects of combination of Inhibace and oral prednisone in pediatric patients with nephrotic syndrome. 45 patients with nephrotic syndrome were selected. Of these, 29 patients were treated with prednisone(2mg/kg/day) and 16 children were treated with prednisone and Inhibace(2.5mg/day). Urinary protein, blood pressure, creatinine clearance, serum creatinine, serum albumin and serum cholesterol were measured in both control and Inhibace group. Also the duration to remission after treatment was compared in both groups. The amounts of proteinuria before and after treatment were not significantly different in both group. The duration to remission of proteinuria was significantly shorter in Inhibace group compared to that in control group. The changes of blood pressure and creatinine clearance were not significant in Inhibace group. In conclusion, the combination therapy of oral prednisone and ACE inhibitor have shortened the duration to remission of proteinuria in nephrotic syndrome of children.
Key words: ACE inhibitor | Nephrotic syndrome | Proteinuria

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