J Korean Soc Pediatr Nephrol > Volume 17(2); 2013 > Article
J Korean Soc Pediatr Nephrol 2013;17(2): 86-91. doi: https://doi.org/10.3339/jkspn.2013.17.2.86
가와사키 질환에서의 신증상과 영상 검사 소견
오지영, 박세진, 김선정, 장광천, 김유리아, 신재일, 김기혁
1연세대학교 의과대학 소아청소년과
2아주대학교 의과대학 소아청소년과*
3국민건강보험 일산병원 핵의학과†
4국민건강보험 일산병원 소아청소년과‡
Renal Manifestations and Imaging Studies of Kawasaki Disease
Ji Young Oh, Se Jin Park, Sun Jung Kim, Gwang-Cheon Jang, Uria Kim, Jae Il Shin, Kee Hyuck Kim
1Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine
2Department of Pediatrics*, Ajou University Hospital, Ajou University School of Medicine
3Department of Nuclear Medicine†, National Health Insurance Corporation Ilsan Hospital
4Department of Pediatrics‡, National Health Insurance Corporation Ilsan Hospital
Corresponding Author: Kee Hyuck Kim ,Tel: 031-900-0520, Fax: 031-900-0343, Email: 031-900-0343
Received: September 20, 2013;  Accepted: October 8, 2013.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons. org/licenses/bync/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Purpose: The aim of this study was to verify renal inflammation following Kawasaki disease (KD) using single photon emission computed tomography along with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT).

From March 2011 to October 2011, 15 patients diagnosed with KD at the National Health Insurance System Ilsan Hospital were enrolled in the study. All patients underwent DMSA renal SPECT to evaluate renal involvement during the acute phase of KD. Urine β2-microglobulin (β2-MG), a marker of renal proximal tubular dysfunction, was also measured to assess renal damage.

Results :
All 15 patients had normal renal function test results. However, microscopic hematuria and pyuria were observed in 13% and 33% of the patients, respectively. Moreover, urine β2-MG was elevated in 46% of the patients. In addition, patients were divided into two groups based on β2-MG level: those with an increased β2-MG level, and those with a normal β2-MG level. No significant differences were found between these two groups in clinical characteristics, laboratory, sonography, and echocardiography findings. All patients’ DMSA renal SPECT scans were normal.

Conclusion :
Our study showed that mild abnormalities in the urinalysis and elevated urine β2-MG were the only findings of renal involvement in KD. However, no aggressive renal manifestations were detected on DMSA renal SPECT.
Key words: Kawasaki disease | Renal complication | Single photon emission computed tomography together with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA) | β2-microglobulin

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