J Korean Soc Pediatr Nephrol > Volume 4(1); 2000 > Article
J Korean Soc Pediatr Nephrol 2000;4(1): 1-5.
소아 단백뇨 검사에 있어서 요비중의 유용성
김종화, 유기환, 홍영숙, 이주원, 김순겸
1고려대학교 의과대학 소아과학 교실
2고려대학교 의과대학 소아과학 교실
3고려대학교 의과대학 소아과학 교실
4고려대학교 의과대학 소아과학 교실
5고려대학교 의과대학 소아과학 교실
Urine Specific Gravity as a Useful Tool for Screening Proteinuria in Children
Jong-Hwa Kim, Kee-Hwan Yoo, Young-Sook Hong, Joo-Won Lee, Soon-Kyum Kim
1Department of Pediatrics, Korea University, College of Medicine
2Department of Pediatrics, Korea University, College of Medicine
3Department of Pediatrics, Korea University, College of Medicine
4Department of Pediatrics, Korea University, College of Medicine
5Department of Pediatrics, Korea University, College of Medicine
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ABSTRACT
Purpose: The plcr of spot urine has been uised to predict the timed urine protein excretion. Although this method reduces errors caused by variations in urine volume, it is relatively thconvenient and expensive. Recently, a more rapid and less expensive screening method with specific gravity(SG) has been reported, and we have examined whether estimated-creatinine(Cr-est) with urine 5G could be used in place of urine creatinine to predict 24-hour collected urine protein excretion in children.
Methods: We had retrospectively analyzed protein, creatinine and urine SG in randomized spot urine samples of 147 patients from March 1998 till June 1998 in Korea university Guro hospital and compared the urinary protein creatinine ratio(P/Cr) with the protein estimated-creatinine ratio(P/Cr-est). We compared the correlation of urinary creatinine vs-urine 5G with the timed urine pretein excretion.
Results : 1) urine SG accurately estimated urine creatinine concentration (r=0.407, P<0.001, Cr=SG x 4485.82-4482.87). 2) P/Cr correlated with urine protein excretion measured in a 24-hour urine collection (r=0.771, P<0.001, 24-hour collected urine protein : 0.338 x (P/Cr) 4+667.885). 3) P/Cr-est correlated with a 24-hour collected urine protein (r=0.723, P<0.001, 24-hour collected urine protein =0.354 x (P/Cr-est)+726.044),
Conclusions : These results suggest that P/Cr-est with urine SG could be useful method for screening proteinuria in children.
Key words: Specific Gravity | Protein/creatinine | Proteinuria

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