Analysis of Factors Affecting Height Growth After Renal Transplantation in Children

Lee, Joo Hoon; Lee, Byong Sop; Kang, Hee-Gyung; Hahn, Hyewon; Lee, Jun Ho; Ha, Il Soo; Cheong, Hae Il; Choi, Yong; Kim, Sang Joon

J Korean Soc Pediatr Nephrol > Volume 4(1); > Article

소아 신이식 후의 키 성장에 영향을 미치는 인자들에 대한 연구

이주훈, 이병섭, 강희경, 한혜원, 이준호, 하일수, 정해일, 최용, 김상준

¹서울대학교 의과대학 소아과학교실
²서울대학교 의과대학 소아과학교실
³서울대학교 의과대학 소아과학교실
⁴서울대학교 의과대학 소아과학교실
⁵서울대학교 의과대학 소아과학교실
⁶서울대학교 의과대학 소아과학교실
⁷서울대학교 의과대학 소아과학교실
⁸서울대학교 의과대학 소아과학교실
⁹서울대학교 의과대학 외과학교실

Analysis of Factors Affecting Height Growth After Renal Transplantation in Children

Joo Hoon Lee, Byong Sop Lee, Hee-Gyung Kang, Hyewon Hahn, Jun Ho Lee, Il Soo Ha, Hae Il Cheong, Yong Choi, Sang Joon Kim

¹Department of Pediatrics, Seoul National University, College of Medicine
²Department of Pediatrics, Seoul National University, College of Medicine
³Department of Pediatrics, Seoul National University, College of Medicine
⁴Department of Pediatrics, Seoul National University, College of Medicine
⁵Department of Pediatrics, Seoul National University, College of Medicine
⁶Department of Pediatrics, Seoul National University, College of Medicine
⁷Department of Pediatrics, Seoul National University, College of Medicine
⁸Department of Pediatrics, Seoul National University, College of Medicine
⁹Department of Surgery, Seoul University, College of Medicine

ABSTRACT

Purpose: To improve the recovery of growth deficit after renal transplantation in children, we analysed the factors affecting height growth after renal transplantation.
Methods: We reviewed medical records of fifty-six children in whom height data were available for three years after transplantation. All height data were converted into Z-scores. We analyzed the effects of sex, age at transplantation, cumulative mean steroid dose for 3 years, serum creatinine levels, height at transplantation, donor source and history of prior dialysis on patients' z-scores and delta Zs.
Results : The Z-scores at transplantation were lower in patients of younger age (P=0.007). When baseline Z-scores were lower, the delta Zs were higher (P<0.01), but the Z-scores after transplantation were still lower (P<0.001). According to the analysis of the partial correlation coefficients, Z-scores and delta Zs at 1 year after transplantation were higher in groups of younger age and of lower steroid dosages (P<0.05). The delta Zs at 6 month and 1 year after transplantation were lower in the group with abnormally higher serum creatinine (P<0.05). There was no difference in Z-scores between groups of different genders, donor sources, and histories of previous dialysis.
Conclusion : The children of younger age, on lower steroid dosage, with less growth retardation at transplantation, and with normal graft function had better height growth recoveries after renal transplantation.