A Case of Hemolysis after Minor ABO Mismatched Kidney Transplantation

Hahn, HyeWon; Ha, Il Soo; Cheong, Hae Il; Choi, Yong

J Korean Soc Pediatr Nephrol > Volume 6(1); 2002 > Article

J Korean Soc Pediatr Nephrol 2002;6(1): 120-122.

ABO 부적합 신이식 후 발생한 용혈 1례

한혜원, 하일수, 정해일, 최용

¹서울대학교 의과대학 소아과학교실
²서울대학교 의과대학 소아과학교실
³서울대학교 의과대학 소아과학교실
⁴서울대학교 의과대학 소아과학교실

A Case of Hemolysis after Minor ABO Mismatched Kidney Transplantation

HyeWon Hahn, Il Soo Ha, Hae Il Cheong, Yong Choi

¹Department of pediatrics, Seoul National University College of Medicine
²Department of pediatrics, Seoul National University College of Medicine
³Department of pediatrics, Seoul National University College of Medicine
⁴Department of pediatrics, Seoul National University College of Medicine

ABSTRACT

A 9-year-old boy of B blood group with end-stage renal disease due to IgA nephropathy received group O kidney transplantation from his father. On day 9, he developed intravascular hemolysis, and anti-B autoantibody formation was confirmed. We diagnosed as immune hemolytic anemia due to passenger lymphocyte from donor, and cyclosporine withdrawl was done. Anemia resolved spontaneously, but on day 18, graft dysfunction developed, and graft biopsy revealed acute allograft rejection. Although hemolysis due to autoantibody is very rare and often mild, and the role of hemoglobinuria on acute rejection in this case is not certain, we recommend consideration of aggressive management on severe hemolysis after minor mismatched kidney transplantation.

Key words: Hemolysis | ABO mismatched kidney transplatation | Autoantibody