Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood Henoch-Schonlein Purpura Nephritis

Huh, Yun-Jung; Shin, Jae-Il; Park, Jee-Min; Jeong, Hyeon-Joo; Lee, Jae-Seung

J Korean Soc Pediatr Nephrol > Volume 7(1); 2003 > Article

J Korean Soc Pediatr Nephrol 2003;7(1): 30-37.

소아 Henoch-Schönlein 자반병 신염의 임상양상 및 병리소견과 임상경과

허윤정, 신재일, 박지민, 정현주, 이재승

¹연세대학교 의과대학 소아과학교실
²연세대학교 의과대학 소아과학교실
³연세대학교 의과대학 소아과학교실
⁴연세대학교 의과대학 병리학교실
⁵연세대학교 의과대학 소아과학교실

Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood Henoch-Schonlein Purpura Nephritis

Yun-Jung Huh, Jae-Il Shin, Jee-Min Park, Hyeon-Joo Jeong, Jae-Seung Lee

¹Department of Pediatrics, Yonsei University College of Medicine
²Department of Pediatrics, Yonsei University College of Medicine
³Department of Pediatrics, Yonsei University College of Medicine
⁴Department of Pathology, Yonsei University College of Medicine
⁵Department of Pediatrics, Yonsei University College of Medicine

ABSTRACT

PURPOSE: Henoch-Schonlein purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven Henoch-Schonlein purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings. METHODS: The clinical features, initial laboratory and pathologic findings, and clinical outcome were evaluated in 60 children with biopsy-proven Henoch-Schonlein purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002. RESULTS: The ratio of male to female patients was 1.2:1. The interval between the onset of Henoch-Schonlein purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome in 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome. CONCLUSION: Renal manifestation and pathologic findings correlated with the clinical outcome. It is necessary to evaluate the correlation between pathologic findings and treatment.

Key words: Henoch-Schonlein purpura nephritis | Pathology | Prognosis