소아 Henoch-Schönlein 자반병 신염의 임상양상 및 병리소견과 임상경과 |
허윤정, 신재일, 박지민, 정현주, 이재승 |
1연세대학교 의과대학 소아과학교실 2연세대학교 의과대학 소아과학교실 3연세대학교 의과대학 소아과학교실 4연세대학교 의과대학 병리학교실 5연세대학교 의과대학 소아과학교실 |
Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood Henoch-Schonlein Purpura Nephritis |
Yun-Jung Huh, Jae-Il Shin, Jee-Min Park, Hyeon-Joo Jeong, Jae-Seung Lee |
1Department of Pediatrics, Yonsei University College of Medicine 2Department of Pediatrics, Yonsei University College of Medicine 3Department of Pediatrics, Yonsei University College of Medicine 4Department of Pathology, Yonsei University College of Medicine 5Department of Pediatrics, Yonsei University College of Medicine |
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ABSTRACT |
PURPOSE: Henoch-Schonlein purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven Henoch-Schonlein purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings. METHODS: The clinical features, initial laboratory and pathologic findings, and clinical outcome were evaluated in 60 children with biopsy-proven Henoch-Schonlein purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002. RESULTS: The ratio of male to female patients was 1.2:1. The interval between the onset of Henoch-Schonlein purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome in 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome. CONCLUSION: Renal manifestation and pathologic findings correlated with the clinical outcome. It is necessary to evaluate the correlation between pathologic findings and treatment. |
Key words:
Henoch-Schonlein purpura nephritis | Pathology | Prognosis |
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