| 소아에서 신장 이식 후 발생한 Posttransplant Lymphoproliferative Disease 1례 |
| 장원경, 한혜원, 이미정, 김태형, 박영서 |
1울산대학교 의과대학 서울아산병원 소아과
2울산대학교 의과대학 서울아산병원 소아과
3울산대학교 의과대학 서울아산병원 소아과
4울산대학교 의과대학 서울아산병원 소아과
5울산대학교 의과대학 서울아산병원 소아과 |
| A Case of Posttransplant Lymphoproliferative Disease Following Renal Transplantation in a Child |
| Won-Kyoung Jhang, Hye-Won Hahn, Mee-Jeung Lee, Thad-T. Ghim, Young-Seo Park |
1Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
2Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
3Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
4Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
5Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center |
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| ABSTRACT |
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Posttransplant lymphoproliferative disease(PTLD) has emerged as a potential life-threatening complication of immunosuppressive therapy after organ transplantation. The occurrence of PTLD is usually associated with an Epstein-Barr virus(EBV) infection in patients who are treated by aggressive immunosuppressive therapy. PTLD is represented by diverse manifestations ranging from reactive lymphoid hyperplasia to high grade malignant lymphoma. This is a case report of a late PTLD in a child. The patient is a 14-year-old girl, who presented as malignant lymphoma 44 months after successful renal transplantation. There was no evidence of EBV infection. On bone marrow study, many neoplastic lymphoid cells were detected. Aggressive chemotherapy for PTLD had resulted in clinical remission. However the patient expired from uncontrolled sepsis and septic shock after 77 days. |
| Key words:
Posttransplant lymphoproliferative disease | EBV | Late-onset | Malignant lymphoma | Kidney transplantation |
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