J Korean Soc Pediatr Nephrol > Volume 8(2); 2004 > Article
J Korean Soc Pediatr Nephrol 2004;8(2): 129-137.
어린이의 일차성 단일 증상성 야뇨증에서 Imipramine과 Desmopressin 복합 약물치료의 효과 및 안전성
여지현, 최정연, 정효석, 이경수, 고철우, 김교순, 김기혁, 김정수, 남궁미경, 박영서, 배기수, 유기환, 박용훈
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 소아과학교실
3영남대학교 의과대학 소아과학교실
4영남대학교 의과대학 예방의학교실
5경북대학교 의과대학 소아과학교실
6건국대학교 의과대학 소아과학교실
7일산병윈 소아과
8청주 성모병원 소아과
9연세대학교 원주의과대학 소아과학교실
10울산대학교 의과대학 소아과학교실
11아주대학교 의과대학 소아과학교실
12고려대학교 의과대학 소아과학교실
13영남대학교 의과대학 소아과학교실
Efficacy and Safety during the Combination Therapy of Imipramine and Desmopressin in Primary Monosymptomatic Nocturnal Enuresis
Ji-Hyun Yeo, Jung-Youn Choi, Hyo-Seok Chung, Kyung-Soo Lee, Cheol-Woo Ko, Kyo-Sun Kim, Kee-Hyuk Kim, Jung-Soe Kim, Mee-Kyung NamGoong, Young-Seo Park, Ki-Soo Pai, Kee-Hwan Yoo, Yong-Hoon Park
1Department of Pediatrics, College of Medicine Yeungnam University
2Department of Pediatrics, College of Medicine Yeungnam University
3Department of Pediatrics, College of Medicine Yeungnam University
4Preventive Medicine, College of Medicine Yeungnam University
5Department of Pediatrics, Kyungpook National University Hospital
6Department of Pediatrics, College of Medicine, KonKuk University
7Department of Pediatrics, NHIC Ilsan Hospital
8Department of Pediatrics, Cheong Ju St. Mary's Hospital
9Department of Pediatrics, Yonsei University Worju College of Medicine
10Department of Pediatrics, Asan Medical Center University of Uisan College of Medicine
11Department of Pediatrics, Ajou University School qf Medicine
12Department of Pediatrics, Korea University College of Medicine
13Department of Pediatrics, College of Medicine Yeungnam University
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Purpose : Nocternal enuresis is a common disorder. Tricyclic antidepressant and desmopressin have been accepted pharmacological treatment for this disorder We conducted a cooperative study to investigate the efficacy and adverse reactions of imipramine, desmopressin and combination treatment in children with primary monosymptomatic nocturnal enuresis(PMNE).
Methods: Data from a large multicenter study were analysed. In the period of 8 months in 2002, the study comprised of 168 children(78 boys and 90 girls, 5 to 15 years old) with PMNE for imipramine, desmopressin or combination treatment. Before treatment a history, physical examination and laboratory tests were performed and the children were observed for 2 weeks. Response rate, adverse reactions and enuresis episodes after stopping drug administration were evaluated after 12-weeks of imipramine, desmopressin or combination of both.
Results : After 4 weeks, the frequency of bed wetting in all treated patients decreased during treatment significantly Even though a 30-50%, reduction in the number of wet nights were 68.6%, 74.4% and 86.1% during 12 weeks treatment by imipramine, desmopressin and both of them respectively, there was no significant difference between them. The most common adverse reaction was decreased appetite from imipramine administration. But no serious drug-related adverse events were reported.
Conclusion : Efficacy of the combination therapy of imipramine and desmopressin in PMNE appears not to be better than either drug alone. It is necessary to pay attention on account of adverse reactions during imipramine treatment even though imipramine and desmopressin were generally well tolerated.
Key words: Primary monosymptomatic nocternal enuresis | Imipramine | Desmopressin | Combination therapy
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