J Korean Soc Pediatr Nephrol > Volume 8(2); 2004 > Article
J Korean Soc Pediatr Nephrol 2004;8(2): 149-158.
소아 특발성 IgA 신병증에서 신 손상의 예후 인자로서 신세뇨관 ICAM-1의 발현
손영호, 강미선, 정우영
1인제대학교 의과대학 부산백병원 소아과학교실
2인제대학교 의과대학 부산백병원 해부병리학교실
3인제대학교 의과대학 부산백병원 소아과학교실
Expression of Tubular Intercellular Adhesion Molecule-1 (ICAM -1) as a Marker of Renal Injury in Children with IgA Nephropathy
Young-Ho Son, Mi-Seon Kang, Woo-Yeong Chung
1Departments of Pediatrics, Inje University. College of Medicine, Busan Paik Hospital,
2Departments of Pathology. Inje University. College of Medicine, Busan Paik Hospital,
3Departments of Pediatrics, Inje University. College of Medicine, Busan Paik Hospital,
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ABSTRACT
Purpose : In order to evaluate the value of the renal expression of ICAM-1 as a marker of renal injury, we analyzed the relationship between abnormal tubular expression of ICAM-1 and histopathological features and clinical manifestations in children with IgA nephropathy (IgAN).
Methods: The clinical data from 43 patients with IgAN were analyzed retrospectively and compared to the histopathologic subclassification proposed by Haas. ICAM-1 in tubular epithelium was assessed using the LSAB(Labeled streptavidine biotin) kit on the renal biopsy specimens.
Results : In 43 patients with primary IgAN, 28 males and 15 females aged $12.2{pm}2.2$ years were studied. There were no differences of renal tubular expression of ICAM-1 between patients with gross hematuria and without gross hematuria. But renal tubular expression of ICAM-1 in patients with proteinuria was significantly higher than that of in patients without proteinuria($78.2{pm}14.19%;vs;55.8{pm}32.20%,;P<0.05$). Renal tubular expression of ICAM-1 was also associated with the severity of histopathological degree using Haas classification method. In subclass I, renal tubular expression of ICAM-1 was significantly lower than those of other subclasses. A significant correlation was found between the tubular expression of ICAM-1 and the total amount of protein in 24 hour collected urine$(r_s=0.47236,;p<0.05)$. But there were no significant correlations between the renal tubular expression of ICAM-1 and interstitial cellular infiltration, tubular atrophy, and interstitial fibrosis respectively(F=0.89, P>0.05; F=0.31, p>0.05; F=0.21, p>0.05).
Conclusion : Renal tubular expression of ICAM-1 can be a useful marker of renal injury in children with IgAN.
Key words: IgA nephropathy | Intercellular adhesion molecule-1 | Renal tubule | Predictive marker | Children
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