J Korean Soc Pediatr Nephrol > Volume 10(2); 2006 > Article
J Korean Soc Pediatr Nephrol 2006;10(2): 182-191.
소아 요로 감염 원인균의 항생제 감수성 고찰(2003-2005)
권영대, 김명진, 김희운, 송진영, 고준태, 강호석, 오세호
1한동대학교 선린병원 소아과
2한동대학교 선린병원 소아과
3한동대학교 선린병원 소아과
4한동대학교 선린병원 소아과
5한동대학교 선린병원 소아과
6한동대학교 선린병원 소아과
7한동대학교 선린병원 소아과
Antibiotic Sensitivity Pattern of Pathogens from Children with UTI
Young-Dae Kwon, Myung-Jin Kim, Hee-Un Kim, Jin-Young Song, Joon-Tae Ko, Ho-Seok Kang, Sei-Ho Oh
1Department of Pediatrics, Sunlin Hospital, Handong University
2Department of Pediatrics, Sunlin Hospital, Handong University
3Department of Pediatrics, Sunlin Hospital, Handong University
4Department of Pediatrics, Sunlin Hospital, Handong University
5Department of Pediatrics, Sunlin Hospital, Handong University
6Department of Pediatrics, Sunlin Hospital, Handong University
7Department of Pediatrics, Sunlin Hospital, Handong University
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ABSTRACT
Purpose : We studied the degree of changes in antibiotic sensitivity toward causative organisms, prevalence and clinical manifestations of extended-spectrum $beta$-lactamase(ESBL)-producers of urinary tract infection(UTI) for a period of three years. This serves to provide useful information in selecting adequate drugs for the treatment of UTI.
Methods : We recruited 137 patients who grew more than $10^5$ CFU/mL in their urine culture among 250 patients who visited and were admitted to Handong University's Sunlin Hospital for UTI treatment from January 2003 to December 2005. We retrospectively analyzed the data from the medical records.
Results : The common pathogenic organisms were Escherichia coli(65.0%), Klepsiella pneumoniae(14.0%), Enterococcus faecalis(5.8%) and Proteus vulgaris(2.9%) in consecutive order. The prevalence of ESBL-producers among isolated E. coli and K. pneumoniae was 4.5%(4 cases) and 14.3%(2 cases), respectively. The antibiotic sensitivity rates of E. coli were relatively high to amikacin(100%), imipenem(100%), ceftriaxone(95.5%) and tobramycin(91.4%) while relatively low to TMP/SMZ(55.4%), ampicillin/sulbactam(29.4%) and ampicillin(24.2%).
Conclusion : The use of ampicillin, ampicillin/sulbactam and TMP/SMZ, which have been the first choices in the treatment of UTI, should be reconsidered due to the low sensitivity rates towards these antibiotics. Due to the high incidence and antibiotic tolerance of ESBL that might have risen from the development of new antibiotics and increased antibiotic use, it is necessary to consider changing the standard antibiotics that have been used in the treatment of UTI.
Key words: Urinary tract infection(UTI) | Antibiotic sensitivity | Extended-spectrum $\beta$- lactamase(ESBL)
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