A Case of Extensive Cerebral Venous Thrombosis in Childhood Nephrotic Syndrome

Son, Chang-Hee; Lee, Eun-Hye; Lee, Joo-Hoon; Park, Young-Seo

J Korean Soc Pediatr Nephrol > Volume 10(2); 2006 > Article

J Korean Soc Pediatr Nephrol 2006;10(2): 238-243.

신증후군 환아에서 발생한 광범위한 뇌정맥 혈전증 1례

손창희, 이은혜, 이주훈, 박영서

¹울산대학교 의과대학 서울아산병원 소아과학교실
²울산대학교 의과대학 서울아산병원 소아과학교실
³울산대학교 의과대학 서울아산병원 소아과학교실
⁴울산대학교 의과대학 서울아산병원 소아과학교실

A Case of Extensive Cerebral Venous Thrombosis in Childhood Nephrotic Syndrome

Chang-Hee Son, Eun-Hye Lee, Joo-Hoon Lee, Young-Seo Park

¹Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
²Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
³Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
⁴Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center

ABSTRACT

Nephrotic syndrome in childhood is known to be associated with a hypercoagulable state and thromboembolic complications, among which cerebral venous thrombosis is a very rare and serious one, with only a few isolated reports in the literature. A 9-year-old boy with known nephrotic syndrome was admitted due to a relapse with massive proteinuria and generalized edema. He complained of a prolonged frontal headache. The enhanced brain magnetic resonance imaging(MRI) showed a high signal in the region of the superior sagittal sinus and right transverse sinus consistent with a thrombus. He was managed with steroids, cyclosporine and warfarin. His headache subsided 2 weeks later and proteinuria resolved 1 month later. An MRI 2 months later was normal. We describe this case and review the literature to emphasize the importance of recognizing this potentially life threatening complication and initiating anticoagulation therapy.

Key words: Cerebral venous thrombosis | Nephrotic syndrome | Childhood