J Korean Soc Pediatr Nephrol > Volume 10(2); 2006 > Article
J Korean Soc Pediatr Nephrol 2006;10(2): 238-243.
신증후군 환아에서 발생한 광범위한 뇌정맥 혈전증 1례
손창희, 이은혜, 이주훈, 박영서
1울산대학교 의과대학 서울아산병원 소아과학교실
2울산대학교 의과대학 서울아산병원 소아과학교실
3울산대학교 의과대학 서울아산병원 소아과학교실
4울산대학교 의과대학 서울아산병원 소아과학교실
A Case of Extensive Cerebral Venous Thrombosis in Childhood Nephrotic Syndrome
Chang-Hee Son, Eun-Hye Lee, Joo-Hoon Lee, Young-Seo Park
1Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
2Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
3Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
4Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center
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ABSTRACT
Nephrotic syndrome in childhood is known to be associated with a hypercoagulable state and thromboembolic complications, among which cerebral venous thrombosis is a very rare and serious one, with only a few isolated reports in the literature. A 9-year-old boy with known nephrotic syndrome was admitted due to a relapse with massive proteinuria and generalized edema. He complained of a prolonged frontal headache. The enhanced brain magnetic resonance imaging(MRI) showed a high signal in the region of the superior sagittal sinus and right transverse sinus consistent with a thrombus. He was managed with steroids, cyclosporine and warfarin. His headache subsided 2 weeks later and proteinuria resolved 1 month later. An MRI 2 months later was normal. We describe this case and review the literature to emphasize the importance of recognizing this potentially life threatening complication and initiating anticoagulation therapy.
Key words: Cerebral venous thrombosis | Nephrotic syndrome | Childhood

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