Two Cases of Acute Renal Failure Complicating Paroxysmal Nocturnal Hemoglobinuria in Children

Ryu, Jung-Min; Ahn, Yo-Han; Lee, So-Hee; Choi, Hyun-Jin; Lee, Beom-Hee; Kang, Hee-Gyung; Kang, Hyoung-Jin; Shin, Hee-Young; Ha, Il-Soo; Cheong, Hae-Il; Ahn, Hyo-Seop; Choi, Yong

doi:2008.12.2.221

J Korean Soc Pediatr Nephrol > Volume 12(2); 2008 > Article

J Korean Soc Pediatr Nephrol 2008;12(2): 221-226. doi: https://doi.org/10.3339/jkspn.2008.12.2.221

급성 신부전을 동반한 발작 야간 혈색소뇨증 2례

류정민, 안요한, 이소희, 최현진, 이범희, 강희경, 강형진, 신희영, 하일수, 정해일, 안효섭, 최용

¹서울대학교 어린이병원 소아청소년과
²서울대학교 어린이병원 소아청소년과
³서울대학교 어린이병원 소아청소년과
⁴서울대학교 어린이병원 소아청소년과
⁵서울대학교 어린이병원 소아청소년과
⁶서울대학교 어린이병원 소아청소년과
⁷서울대학교 어린이병원 소아청소년과
⁸서울대학교 어린이병원 소아청소년과
⁹서울대학교 어린이병원 소아청소년과
¹⁰서울대학교 어린이병원 소아청소년과
¹¹서울대학교 어린이병원 소아청소년과
¹²서울대학교 어린이병원 소아청소년과

Two Cases of Acute Renal Failure Complicating Paroxysmal Nocturnal Hemoglobinuria in Children

Jung-Min Ryu, Yo-Han Ahn, So-Hee Lee, Hyun-Jin Choi, Beom-Hee Lee, Hee-Gyung Kang, Hyoung-Jin Kang, Hee-Young Shin, Il-Soo Ha, Hae-Il Cheong, Hyo-Seop Ahn, Yong Choi

¹Department of Pediatrics, Seoul National University Childrens Hospital
²Department of Pediatrics, Seoul National University Childrens Hospital
³Department of Pediatrics, Seoul National University Childrens Hospital
⁴Department of Pediatrics, Seoul National University Childrens Hospital
⁵Department of Pediatrics, Seoul National University Childrens Hospital
⁶Department of Pediatrics, Seoul National University Childrens Hospital
⁷Department of Pediatrics, Seoul National University Childrens Hospital
⁸Department of Pediatrics, Seoul National University Childrens Hospital
⁹Department of Pediatrics, Seoul National University Childrens Hospital
¹⁰Department of Pediatrics, Seoul National University Childrens Hospital
¹¹Department of Pediatrics, Seoul National University Childrens Hospital
¹²Department of Pediatrics, Seoul National University Childrens Hospital

ABSTRACT

Paroxysmal nocturnal hemoglobinuria(PNH) is an acquired hematologic disorder characterized by intravascular hemolysis, nocturnal hemoglobinuria, thrombotic events and bone marrow failure. It rarely occurs in children and can be complicated by acute renal failure(ARF). Here, we present two cases of ARF complicating PNH which has not been reported yet in Korean children. We suggest that PNH should be considered in differential diagnosis of ARF in children associated with intravascular hemolysis.

Key words: Paroxysmal nocturnal hemoglobinuria(PNH) | Acute renal failure | Intravascular hemolysis | Children