Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy

Hahn, Won-Ho; Suh, Jin-Soon; Cho, Byoung-Soo

doi:2010.14.1.51

J Korean Soc Pediatr Nephrol > Volume 14(1); 2010 > Article

J Korean Soc Pediatr Nephrol 2010;14(1): 51-61. doi: https://doi.org/10.3339/jkspn.2010.14.1.51

소아 IgA 신병증 환자에서 임상병리 양상과 CCL-2 및 CCL-5 유전자 다형성의 연관성 연구

한원호, 서진순, 조병수

¹경희대학교 의과대학 소아과학교실, 경희대학교 동서신장병 연구소
²경희대학교 의과대학 소아과학교실, 경희대학교 동서신장병 연구소
³경희대학교 의과대학 소아과학교실, 경희대학교 동서신장병 연구소

Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy

Won-Ho Hahn, Jin-Soon Suh, Byoung-Soo Cho

¹Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University
²Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University
³Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University

Received: March 27, 2010; Revised: April 13, 2010. Accepted: April 21, 2010.

ABSTRACT

Purpose : Previous studies have suggested that Chemokine (C-C motif) ligand-2 (CCL-2; also known as MCP-1) and CCL-5 (also known as RANTES) are possibly associated with the pathogenesis of various inflammatory and non-inflammatory renal diseases. The present study was conducted to investigate association of polymorphisms of CCL-2 and CCL-5 genes with childhood IgA nephropathy (IgAN).
Methods : The authors analyzed six single nucleotide polymorphisms (SNPs) of CCL-2 and CCL-5 in 196 pediatric IgAN patients and in 285 healthy controls. We compared variations in SNPs between two several sets of IgAN subgroups, allocated by presence of proteinuria (>4 mg/$m^2$/hour), podocyte foot process effacement, and pathologically advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis.
Results : Genotypic data of IgAN patients and controls showed no significant SNP frequency difference in both of of CCL-2 and CCL-5. Even though two linkage disequilibrium blocks were formed, there was no significance in the haplotype analysis. In the patient subgroup analysis, no SNP of CCL-2 and CCL-5 was found to be associated with the presence of proteinuria, podocyte foot process effacement, and pathologically advanced disease markers.
Conclusion : Our data indicate that no association exists between CCL-2 and CCL-5 SNPs and childhood IgAN susceptibility, and presence of proteinuria, podocyte foot process effacement, and pathologic progression of IgAN.