J Korean Soc Pediatr Nephrol > Volume 15(1); 2011 > Article
J Korean Soc Pediatr Nephrol 2011;15(1): 29-37. doi: https://doi.org/10.3339/jkspn.2011.15.1.29
사구체신염의 병리 - 표본제작 및 기본병변 -
영남대학교 의과대학 병리학교실
Pathology of Glomerulonephritis - Specimen Preparation and Basic Pathologic Changes -
Yong-Jin Kim
Department of Pathology, Yeungnam University College of Medicine
Received: February 11, 2011;  Accepted: March 18, 2011.
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To understand the course of renal diseases well, we must have basic knowledges of histologic procedures of renal biopsy samples as well as basic pathologic changes. This article describes the method of dividing the biopsy samples, fixatives for various pathologic examinations and basic pathologic changes of glomerular diseases. For light microscopic examination, color changes of glomerular structures in PAS, trichrome and PAM stains, normal glomerular patterns compared to various glomerulopathies are introduced. While describing typical staining patterns and intensities of fluorescence in membranous glomerulopathy and IgA nephropathy, basic interpretation of immunofluorescent microscopic examination is described. To understand electron microscopic pictures of renal diseases, preference locations of electron dense deposits in various glomerulonephrites are described with schema. This article is the introduction part of the renal pathology and for the further detail changes of specific entities, we should reference the renal pathology textbooks or articles.
Key words: Glomerulonephritis | Pathology | Renal biopsy | Light microscopy | Immunofluorescence microscopy | Immunohistochemistry | Electron microscopy
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