J Korean Soc Pediatr Nephrol > Volume 15(2); 2011 > Article
Journal of the Korean Society of Pediatric Nephrology 2011;15(2): 116-124. doi: https://doi.org/10.3339/jkspn.2011.15.2.116
급성 신손상의 생물학적 표지자
조민현
경북대학교 의학전문대학원 소아과학교실
Biomarkers in Acute Kidney Injury
Min-Hyun Cho
Department of Pediatrics, Kyungpook National University School of Medicine
Received: August 18, 2011;  Accepted: September 5, 2011.
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ABSTRACT
Acute kidney injury (AKI) can result in mortality or progress to chronic kidney disease in hospitalized patients. Although serum creatinine has long been used as the best biomarker for diagnosis of AKI, it has some clinical limitations, especially in children. New biomarkers are needed for early diagnosis, differential diagnosis, and reliable prediction of prognosis in AKI. Up to the present, candidate AKI biomarkers include neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), livertype fatty acid-binding protein (L-FABP), matrix metalloproteinase-9 (MMP-9), and Nacetyl-$ss$-D-glucosaminidase (NAG). However, whether these are superior to serum creatinine in the confirmation of diagnosis and prediction of prognosis in AKI is unclear. Further studies are needed for clinical application of these new biomarkers in AKI.
Key words: Acute kidney injury | Biomarker | Children | NGAL | KIM-1 | IL-18 | L-FABP

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