J Korean Soc Pediatr Nephrol > Volume 16(1); 2012 > Article
Journal of the Korean Society of Pediatric Nephrology 2012;16(1): 1-8. doi: https://doi.org/10.3339/jkspn.2012.16.1.1
야뇨증의 병인 기전 -항이뇨호르몬, 고칼슘뇨증, 용질성 이뇨
서울대학교병원 소아청소년과
Circadian Rhythm of ADH, Hypercalciuria, and Solute Diuresis as Pathogenesis of Enuresis
Hee-Gyung Kang
Department of Pediatrics, Seoul National University Children's Hospital
Received: March 19, 2012;  Accepted: April 7, 2012.
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Nocturnal polyuria is one of the main pathogenic mechanisms of enuresis. Disturbance of circadian rhythm of antidiuretic hormone (ADH or AVP), hypercalciuria, and/or solute diuresis are considered to cause nocturnal polyuria, which in turn causes enuresis in patients with relatively small bladder capacity and high threshold for awakening. Evaluation of these factors would guide the therapeutic approach for enuresis.
Key words: Enuresis | Nocturnal polyuria | Circadian rhythm | Antidiuretic hormone | Solute diuresis
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