The Significance of Interleukin-6 in Henoch-Schönlein Purpura Nephritis in Children

Lee, Jae-Seung; Kwon, Min-Joong

J Korean Soc Pediatr Nephrol > Volume 1(2); 1997 > Article

J Korean Soc Pediatr Nephrol 1997;1(2): 130-135.

Henoch-Schönlein Purpura 신염에서 Interleukin-6의 의의

이재승, 권민중

¹연세대학교 의과대학 소아과학교실
²연세대학교 의과대학 소아과학교실

The Significance of Interleukin-6 in Henoch-Schönlein Purpura Nephritis in Children

Jae-Seung Lee, Min-Joong Kwon

¹Department of Pediatrics, Yonsei University, College of Medicine
²Department of Pediatrics, Yonsei University, College of Medicine

ABSTRACT

Purpose : Interleukin-6(IL-6), a multifunctional cytokine, has been found to have growth and differentiation activities on a wide variety of tissues and cells, including mesangial cells. It has been known that IL-6 is an autocrine growth factor for the proliferation of mesangial cells. Several studies have been performed for revealing the clinical significance of IL-6 in mesangial proliferative glomerulonephritis.
Methods : The author measured serum and urinary IL-6 in 30 patients with $Henoch-Sch""{o}nlein$ purpura (HSP), 18 patients with HSP nephritis, and 10 normal children as a control group.
Results : The serum level of IL-6 was increased significantly in the patients with HSP and HSP nephritis compared to normal control. The level of urinary IL-6 was increased significantly in the patients with HSP nephritis compared to both HSP and normal control groups. The level of urinary IL-6 was not correlated with the level of serum.
Conclusion : IL-6 was correlated with the amount of proteinuria. These data suggest that IL-6 may be involved in the pathological proliferation of mesangial cell in HSP nephritis.

Key words: Interleukin-6 | $Henoch-Sch\""{o}nlein$ purpura | $Henoch-Sch\""{o}nlein$ purpura nephritis