Increased Frequency of Apolipoprotein E4 Genotype in Childhood Minimal Change Nephrotic Syndrome (MCNS)

Kim, Sung-Do; Bae, Young-Min; Cho, Byoung-Soo; Cho, Yoe-Won; Kim, Il-Soo

J Korean Soc Pediatr Nephrol > Volume 5(2); 2001 > Article

J Korean Soc Pediatr Nephrol 2001;5(2): 87-99.

소아 미세변화 신증후군 환자에서 Apolipoprotein E4 유전자형에 관한 연구

김성도, 배영민, 조병수, 조여원, 김일수

¹경희대학교 의과대학 부속병원 소아과학 교실
²경희대학교 의과대학 부속병원 소아과학 교실
³경희대학교 의과대학 부속병원 소아과학 교실
⁴경희대학교 의과대학 부속병원 동서 의학 대학원
⁵경희대학교 의과대학 부속병원 동서 의학 대학원

Increased Frequency of Apolipoprotein E4 Genotype in Childhood Minimal Change Nephrotic Syndrome (MCNS)

Sung-Do Kim, Young-Min Bae, Byoung-Soo Cho, Yoe-Won Cho, Il-Soo Kim

¹Department of Pediatrics School of Medicine, Kyunghee University
²Department of Pediatrics School of Medicine, Kyunghee University
³Department of Pediatrics School of Medicine, Kyunghee University
⁴Kyunghee Oriental and Western medical graduate school, Kyunghee University
⁵Kyunghee Oriental and Western medical graduate school, Kyunghee University

ABSTRACT

Purpose: We studied to find out apo-E genotype polymorphism in minimal change nephrotic syndrome(MCNS) and IgA nephropathy(IgAN) and to determine the relationship between apo-E genotype and clinical course of MCNS. Materials and
Method : 43 MCNS patients and 15 IgAN patients were examined for apo-E polymorphism. 50 healthy blood donors were examined for apo-E genotype as control. Genomic DNA was prepared front peripheral blood leukocytes according to standard procedures.
Results : As compared with control group, e4 allele frequency was significantly increased in MCNS (p<0.01). However, in IgAN e2 allele frequency, however, was 2.6 times higher than normal control (P<0.01). The frequency of e4 allele of frequent relapser group was 4.6 times higher than normal control and was 2 times higher than infrequent relapser group.
Conclusion : We think that apo-E typing might be one of the parameters, which should be considered to predict the course of MCNS in children. MCNS with risky HLA profile and E4/4 genotype could indicate the need for a longer steroid administration. And apo-E genotype needs to be considered for the evaluation of therapeutic responses to other drugs. (J, Korean Soc Pediatr Nephrol 2001 ; 5 : 87-99)

Key words: apolipoprotein E (apo-E) | Polymorphism | Minimal Change Nephrotic Syndrome(MCNS) | IgA nephropathy (IgAU)