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Journal of the Korean Society of Pediatric Nephrology 2001;5(2): 87-99.
소아 미세변화 신증후군 환자에서 Apolipoprotein E4 유전자형에 관한 연구
김성도, 배영민, 조병수, 조여원, 김일수
1경희대학교 의과대학 부속병원 소아과학 교실
2경희대학교 의과대학 부속병원 소아과학 교실
3경희대학교 의과대학 부속병원 소아과학 교실
4경희대학교 의과대학 부속병원 동서 의학 대학원
5경희대학교 의과대학 부속병원 동서 의학 대학원
Increased Frequency of Apolipoprotein E4 Genotype in Childhood Minimal Change Nephrotic Syndrome (MCNS)
Sung-Do Kim, Young-Min Bae, Byoung-Soo Cho, Yoe-Won Cho, Il-Soo Kim
1Department of Pediatrics School of Medicine, Kyunghee University
2Department of Pediatrics School of Medicine, Kyunghee University
3Department of Pediatrics School of Medicine, Kyunghee University
4Kyunghee Oriental and Western medical graduate school, Kyunghee University
5Kyunghee Oriental and Western medical graduate school, Kyunghee University
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ABSTRACT
Purpose: We studied to find out apo-E genotype polymorphism in minimal change nephrotic syndrome(MCNS) and IgA nephropathy(IgAN) and to determine the relationship between apo-E genotype and clinical course of MCNS. Materials and
Method : 43 MCNS patients and 15 IgAN patients were examined for apo-E polymorphism. 50 healthy blood donors were examined for apo-E genotype as control. Genomic DNA was prepared front peripheral blood leukocytes according to standard procedures.
Results : As compared with control group, e4 allele frequency was significantly increased in MCNS (p<0.01). However, in IgAN e2 allele frequency, however, was 2.6 times higher than normal control (P<0.01). The frequency of e4 allele of frequent relapser group was 4.6 times higher than normal control and was 2 times higher than infrequent relapser group.
Conclusion : We think that apo-E typing might be one of the parameters, which should be considered to predict the course of MCNS in children. MCNS with risky HLA profile and E4/4 genotype could indicate the need for a longer steroid administration. And apo-E genotype needs to be considered for the evaluation of therapeutic responses to other drugs. (J, Korean Soc Pediatr Nephrol 2001 ; 5 : 87-99)
Key words: apolipoprotein E (apo-E) | Polymorphism | Minimal Change Nephrotic Syndrome(MCNS) | IgA nephropathy (IgAU)
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