J Korean Soc Pediatr Nephrol > Volume 2(2); 1998 > Article
J Korean Soc Pediatr Nephrol 1998;2(2): 118-124.
Henoch-Schönlein(HS) 신염에서 장기 스테로이드와 Azathioprine의 병합치료 효과
문경상, 진소영, 김은미
1순천향대학교 의과대학 소아과학교실
2순천향대학교 의과대학 임상병리학교실
3순천향대학교 의과대학 소아과학교실
The Effect of Long-term Steroid Therapy Combined with Azathioprine in Henoch-Schönlein Nephritis
Kyoung-Sang Moon, So-Young Jin, Eun-Mi Kim
1Department of Pediatrics, Soon Chun Hyang University, College of Medicine
2Department of Anatomical Pathology, Soon Chun Hyang University, College of Medicine
3Department of Pediatrics, Soon Chun Hyang University, College of Medicine
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Purpose : There is no specific treatment guidelines for Henoch-$Sch{ddot{o}}nlein$(HS) nephritis. Therefore we performed this study to observe the effect of long term steroid therapy combined with azathioprine
Methods : Treatment protocols; 1) Steroid pulse therapy: methylprednisolon 30 mg/kg/dose, maximum 1 gm, intravenolisly 6 times for alternate day. 2) Oral steroid was given 2 mg/kg/day for 1 month, 1 mg/kg/day for following 1 month and alternate day oral steroid combined with azathioprine 2 mg/kg/day for 2 years.
Results : Time period from HSP to onset of HS nephritis was between 2 weeks to 5 months with mean $7.4{pm}7.4$ weeks. Clinical remission were seen in 4 cases out of 5 ($80%$). Mean time period with disappearance of proteinuria and microscopic hematuria were $5{pm}2.4$ month and $13.3{pm}2.9$ month respectively. On pathologic findings by ISKDC, 3 cases were grade IIIb, 2 cases were grade IV in first kidney biopsies and showed pathologic improvement in follow up tidneybiopsiesafterlyearstreatment.
Conclusion : As there is no definitive treatment for HS nephritis so far, our study of long term oral steroid therapy with azathioprine was effective in clinical and histologic aspect. Therefore further study in HS nephritis with in a large group will be needed in the future.
Key words: HS nephritis | azathioprine

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