Effect of 1-α(OH)D3 on Steroid Induced Bone Loss in Frequently Relapsing Childhood Nephrotic Syndrome

Cho, Byoung-Soo; Kim, Deog-Yoon

J Korean Soc Pediatr Nephrol > Volume 1(1); 1997 > Article

J Korean Soc Pediatr Nephrol 1997;1(1): 13-16.

빈회재발형 소아 신증후군에서 스테로이드에 의한 골다공증에 미치는 1-α(OH)D3의 효과

조병수, 김덕윤

¹경희대학교 의과대학 소아과학교실
²경희대학교 의과대학 내과학교실

Effect of 1-α(OH)D3 on Steroid Induced Bone Loss in Frequently Relapsing Childhood Nephrotic Syndrome

Byoung-Soo Cho, Deog-Yoon Kim

¹Department of Pediatrics, Kyung Hee University College of Medicine
²Department of Nuclear Medicine, Kyung Hee University College of Medicine

ABSTRACT

Steroid induced bone loss is a serious problem in frequently relapsing nephrotic syndrome especially in growing children. In order to evaluate whether 1-(OH)D₃ (IL Sung Pharma.Co.) is effective in preventing steroid induced bone loss, we gave 0.5ug of 1-(OH)D₃ for one year to forty patients with frequently relapsing nephrotic syndrome, receiving longterm prednisolone therapy (mean duration 50.12+/-29.40 months). We checked the following markers before and after 1-(OH)D₃ therapy. i.e. bone mineral density(BMD) using dual energy X-ray absorptiometry(DEXA) at the 2nd to 4th lumbar spine, serum calcium, phosphorus, parathyroid hormone(PTH), osteocalcin and urine pyridinoline(U-PYD). BMD(g/cm²) was increased even steroid therapy from 0.71+/-0.0 to 0.73+/-0.0 (p<0.05). Lumbar spine BMD is a sensitive marker for evaluating steroid induced bone loss in children receiving longterm corticosteroid therapy and that 1-(OH)D₃ appears to be effective in treating and preventing steroid induced bone loss.

Key words: 1-α(OH)D3 | Steroid | Bone mineral density | Nephrotic syndrome