Effect of 1-α(OH)D3 on Steroid Induced Bone Loss in Frequently Relapsing Childhood Nephrotic Syndrome

Cho, Byoung-Soo; Kim, Deog-Yoon

J Korean Soc Pediatr Nephrol > Volume 1(1); 1997 > Article

J Korean Soc Pediatr Nephrol 1997;1(1): 13-16.

빈회재발형 소아 신증후군에서 스테로이드에 의한 골다공증에 미치는 1-α(OH)D3의 효과

조병수, 김덕윤

¹경희대학교 의과대학 소아과학교실
²경희대학교 의과대학 내과학교실

Effect of 1-α(OH)D3 on Steroid Induced Bone Loss in Frequently Relapsing Childhood Nephrotic Syndrome

Byoung-Soo Cho, Deog-Yoon Kim

¹Department of Pediatrics, Kyung Hee University College of Medicine
²Department of Nuclear Medicine, Kyung Hee University College of Medicine

ABSTRACT

Steroid induced bone loss is a serious problem in frequently relapsing nephrotic syndrome especially in growing children. In order to evaluate whether $1-(OH)D_3$ (IL Sung Pharma.Co.) is effective in preventing steroid induced bone loss, we gave $0.5{mu}g$ of $1-(OH)D_3$ for one year to forty patients with frequently relapsing nephrotic syndrome, receiving longterm prednisolone therapy (mean duration $50.12{pm}29.40$ months). We checked the following markers before and after $1-(OH)D_3$ therapy. i.e. bone mineral density(BMD) using dual energy X-ray absorptiometry(DEXA) at the 2nd to 4th lumbar spine, serum calcium, phosphorus, parathyroid hormone(PTH), osteocalcin and urine pyridinoline(U-PYD). BMD($g/cm^2$) was increased even steroid therapy from $0.71{pm}0.0;to;0.73{pm}0.0$ (p<0.05). Lumbar spine BMD is a sensitive marker for evaluating steroid induced bone loss in children receiving longterm corticosteroid therapy and that $1-(OH)D_3$ appears to be effective in treating and preventing steroid induced bone loss.

Key words: $1-{\alpha}(OH)D_3$ | Steroid | Bone mineral density | Nephrotic syndrome